Objective:To justify the use of African mistletoe(AM) Viscum album {V.album) in folkoric medicine to treat diabetes.Methods:In one experiment,the fasting blood glucose(FBG) leveb of diabetic rats were monitored for 4 h.Diabetic rats were treated with AM at doses of 50 mg/kg(AM1) and 100 mg/kg(AM2),glibenclamide(GB)(positive control) and saline solution(SS).In another experiment,diabetic rats were treated with AM2,GB and SS daily for 3 weeks.Results:AM1 and AM2 elicited significant(P<0.05) hypoglycaemic effects within 4 h of extract administration. AM1 and AM2 decreased the FBG by 41%and 49%,respectively,at 2 h.AM2 was found to lower FBC by 51%,relative to baseline,which was comparable to GB at 3 h.In the second experiment, AM2 and GB significantly(P<0.05) decreased the FBG by 34%and 51%,respectively.This was followed by marked decrease in levels of HbAlC in AM2- and GB- treated diabetic rats.AM2 significantly(P<0.05) decreased the STZ-induced increase in levels of serum triglyceride,urea, lactate dehydrogenase,α-amylase and low-density lipoprotein-cholesterol.Furthermore, diabetic rats treated with AM2 had significanlly(P<0.05) elevated high-density lipoprotein-cholesterol. In contrast,STZ administration produced insignificant(P<0.05) effect on the levels of serum creatinine and total bilirubin.Conclusions:Extract of African mistletoe has anti-diabetic and anti-hyperlipidemic effects in STZ-diabetic rats.AM may find clinical application in the amelioration of diabetes-induced lipid disorders. Objective: To justify the use of African mistletoe (AM) Viscum album {V. album) in folkoric medicine to treat diabetes. Methods: In one experiment, the fasting blood glucose (FBG) leveb of diabetic rats were monitored for 4 h. Rats were treated with AM at doses of 50 mg / kg (AM1) and 100 mg / kg (AM2), glibenclamide (GB) (positive control) and saline solution AM1 and AM2 decreased the FBG by 41% and 49%, respectively, at 2 h. AM2 was significantly lower than that of AM2 was significantly increased (P <0.05) found to lower FBC by 51%, relative to baseline, which was comparable to GB at 3 h. the second experiment, AM2 and GB significantly (P <0.05) decreased the FBG by 34% and 51% respectively. This was followed by marked decrease in levels of HbAlC in AM2- and GB-treated diabetic rats. AM2 significantly (P <0.05) decreased the STZ-induced increase in levels of serum triglyceride, ur In contrast, STZ administration produced insignificant (P <0.05). In contrast, STZ administration produced insignificant (P <0.05) ea, lactate dehydrogenase, α-amylase and low-density lipoprotein- effect on the levels of serum creatinine and total bilirubin. Conclusions: Extract of African mistletoe has anti-diabetic and anti-hyperlipidemic effects in STZ-diabetic rats. AM may find clinical application in the amelioration of diabetes-induced lipid disorders.