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本文报告了甲基丙烯酸β-羟乙酯低温辐射聚合固定抗癌药物的研究结果。探讨了亲水性单体、疏水性单体、交联剂、辐射剂量以及聚合物结构、药物含量等因素对固定抗癌药物氟尿嘧啶释放速率的影响,研究发现氟尿嘧啶的释放遵从扩散机制,释放的质量分数(w)与释放时间(t)之间,有W∞t~(0.5)的关系。对于丝裂霉素、平阳霉素等抗癌药物的慢释放体系也作了初步研究。
This paper reports the results of the study on the immobilization of anti-cancer drugs by β-hydroxyethyl methacrylate at low temperature. The effects of hydrophilic monomer, hydrophobic monomer, crosslinking agent, radiation dose, polymer structure, drug content and other factors on the release rate of fluorouracil fixed anticancer drug were investigated. It was found that the release of fluorouracil followed the diffusion mechanism and released Between the mass fraction (w) and the release time (t), there is a relationship of W∞t ~ (0.5). For mitomycin, Pingyangmycin and other anti-cancer drugs slow release system also made a preliminary study.