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目的：探讨ＨＬＡＤＲ抗原在人类巨细胞病毒（ＨＣＭＶ）感染和肾移植排斥患者外周血Ｔ淋巴细胞上的表达及临床意义。方法：用流式细胞仪检测肾功能正常１０例、慢性排斥而无ＣＭＶ感染（血肌酐２００～５００μｍｏｌ／Ｌ）８例、ＣＭＶ活动性感染６例、对照组６例４组的ＨＬＡＤＲ抗原的表达。结果：排斥组和活动性感染组ＨＬＡＤＲＣＤ８＋细胞表达明显增高，４组ＣＤ４＋细胞的表达无显著差异，且ＨＣＭＶ感染组ＣＤ４＋／ＣＤ８＋比率倒置。结论：ＣＤ８＋在抗病毒免疫中起重要作用；ＨＣＭＶ亦可引起Ｔ淋巴细胞激活，参与免疫反应，诱发排斥反应的发生。
Objective: To investigate the expression and clinical significance of HLADR antigen in peripheral blood T lymphocytes from human cytomegalovirus (HCMV) infection and renal allograft rejection. Methods: Flow cytometry was used to detect normal renal function in 10 cases, chronic rejection without CMV infection (serum creatinine 200 ~ 500μmol / L) in 8 cases, CMV active infection in 6 cases, control group, 6 cases in 4 groups HLADR antigen expression. Results: The expression of HLADRCD8 + cells in rejection group and active infection group were significantly higher than those in the control group. There was no significant difference in the expression of CD4 + cells between the four groups and the upregulation of CD4 + / CD8 + ratio in HCMV infection group. Conclusion: CD8 + plays an important role in anti-viral immunity. HCMV can also induce T lymphocyte activation, participate in immune response and induce rejection.