新喹诺酮类抗菌药的抗菌活性系特异作用于细菌的ＤＮＡ聚合酶，阻碍ＤＮＡ的复制而起杀菌作用，由于其抗菌谱广而作用强，与其他抗菌药物之间尚无交叉耐药现象，故近年来的临床应用较为广泛。但近年来的资料亦表明，这类药物虽对一些敏感菌有确切的作用，如果应用不当，且能引起诸多不良甚至较为严重的后果。本文综述了新喹诺酮类药物的临床应用进展，并着重阐述了此类抗菌药物的不良反应及与其他药物的相互作用，以供同道临床用药时参考 The antibacterial activity of the new quinolone antibacterials is a DNA polymerase that specifically acts on bacteria to hinder the DNA replication and play a bactericidal effect. Because of its broad antibacterial spectrum and strong antimicrobial activity, there is no cross-resistance with other antimicrobial agents In recent years, the clinical application is more extensive. However, the data in recent years also show that although these drugs have definite effects on some sensitive bacteria, they can cause many undesirable and even serious consequences if they are not used properly. This review summarizes the clinical application of new quinolones and highlights the adverse reactions of such antibiotics and their interactions with other drugs for reference in fellow clinical practice