论文部分内容阅读
目的探讨重度子痫前期患者血清超敏C反应蛋白(hs-CRP)及髓过氧化物酶(MPO)水平与新生儿出生体重的相关性。方法选取2015年1月-2016年3月在庆阳市妇幼保健计划生育服务中心产科产检及住院分娩的重度子痫前期孕妇80例为研究组,以发病时孕周为准,将发病时孕周<34周孕妇设为早发子痫组,将孕周≥34周孕妇设为晚发子痫组,各40例;选取同期正常妊娠晚期孕妇80例为健康对照组,根据孕周<34周和≥34周分为健康A组和健康B组,各40例。检测和对比血清hs-CRP、MPO水平。结果早发子痫组与晚发子痫组hs-CRP水平均高于同期对照组,差异均有统计学意义(均P<0.05);而早发子痫组与晚发子痫组比较差异无统计学意义(P>0.05)。早发子痫组及晚发子痫组孕妇的MPO表达高于同期对照组,差异有统计学意义(P<0.05),且早发子痫组高于晚发子痫组,差异有统计学意义(P<0.05),但对照组两组比较差异无统计学意义(P>0.05)。早发子痫组与晚发子痫组hs-CRP、MPO水平与新生儿出生体重均呈负相关关系(P<0.05);健康对照组则与出生体重无相关性(P>0.05)。结论在子痫前期的病理生理发展过程中,血清hs-CRP、MPO可能发挥重要作用。重度子痫前期病患的血清hs-CRP、MPO水平的升高可导致胎儿宫内生长发育受限(FGR),导致新生儿体重下降。
Objective To investigate the relationship between serum hs-CRP, MPO and birth weight in severe preeclampsia. Methods From January 2015 to March 2016, 80 pregnant women with severe preeclampsia in obstetric examination and hospital delivery in Qingyang MCH center were selected as the research group. The gestational age at onset was taken as the criterion. Weeks <34 weeks pregnant women as premature eclampsia group, the gestational age≥34 weeks pregnant women as late eclampsia group, 40 cases each; select the same period of normal pregnancy, 80 pregnant women as the healthy control group, according to gestational age <34 Weeks and ≥34 weeks were divided into healthy group A and healthy group B, 40 cases each. The levels of serum hs-CRP and MPO were detected and compared. Results The levels of hs-CRP in early-onset eclampsia group and late-onset eclampsia group were significantly higher than those in the control group (all P <0.05), while those in early-onset eclampsia group and late-onset eclampsia group were significantly different No statistical significance (P> 0.05). The expression of MPO in premature eclampsia group and late eclampsia group was higher than that in the control group at the same period, the difference was statistically significant (P <0.05), and the early onset eclampsia group was higher than the late eclampsia group, the difference was statistically (P <0.05), but there was no significant difference between the two groups (P> 0.05). There was a negative correlation between hs-CRP, MPO levels and birth weight in premature eclampsia group and late eclampsia group (P <0.05). There was no correlation between healthy children and birth weight (P> 0.05). Conclusion Serum hs-CRP and MPO may play an important role in the pathophysiology of preeclampsia. Serum levels of hs-CRP and MPO in patients with severe preeclampsia can lead to limited intrauterine growth restriction (FGR), leading to a decrease in newborn weight.