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以15～16天孕龄胚胎小鼠大脑皮层神经细胞原代分离培养模型,观察8.6～10毫克％的酪氨酸对发育中的脑神经细胞的影响。以探讨临床新生儿一过性高酪氨酸血症产生远期智力发育障碍的机理。初步结果证实高浓度酪氨酸对细胞形态及r氨基丁酸-谷氨酸脱羧酶系统的发育无明显影响。产生远期智力发育障碍可能通过其它途径。
Primary cultured rat cerebral cortex neurons isolated from 15-16 day old embryos were cultured to observe the effects of 8.6 ~ 10 mg% tyrosine on developing brain neurons. To investigate the clinical neonatal transient tyrosinemia caused by long-term mental retardation mechanism. The preliminary results confirmed that high concentration of tyrosine had no significant effect on the cell morphology and the development of r-aminobutyric acid-glutamic acid decarboxylase system. Produce long-term mental retardation may go through other ways.