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目的观察肌萎缩侧索硬化症认知受损的核磁共振成像情况。方法选择2013年1月~2014年12月至我院进行ALS治疗的患者共计15例,按照是否有认知受损分为观察组和对照组,有认知受损患者为观察组,共计6例,无认知受损患者为观察组,共计9例,对两组患者神经心理学相关指标以及MRI结果进行比较。结果观察组患者在Mo CA、FAB、动物列名数、命名错误数、相似性测验得分、画钟测验得分6个项目中与对照组有统计学差异(P<0.05),其他项目组间比较无统计学差异(P>0.05)。MRI检测发现,与对照组比较,观察组在左侧壳核、苍白球、嗅皮层、直回以及左侧额下回三角部、眶部、岛叶部分脑区灰质密度显著增加。结论 MRI能够为ALS患者认知功能损害的临床诊断提供影像学依据。
Objective To observe the cognitive impairment of amyotrophic lateral sclerosis (MRI). Methods A total of 15 patients were enrolled in our hospital from January 2013 to December 2014. The patients with cognitive impairment were divided into observation group and control group according to whether there were cognitive impairment or not, Cases, no cognitive impairment patients for the observation group, a total of 9 cases, the two groups of neuropsychological indicators and MRI results were compared. Results The observation group had statistically significant differences (P <0.05) among the six items of MoCA, FAB, animal column name, naming error, similarity test score and draw bell test score (P <0.05) No statistical difference (P> 0.05). MRI examination showed that compared with the control group, the gray matter density of the observation group in the left putamen, globus pallidus, olfactory cortex, straight back and the left lower frontal gyrus triangle, orbital and insula were significantly increased. Conclusion MRI can provide imaging evidence for the clinical diagnosis of cognitive impairment in patients with ALS.