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生物信息学工具可以用于根据蛋白质的三维结构以及相似的氨基酸序列对蛋白质进行分类,而通过对各类蛋白的特性进行分析可预测蛋白质的潜在致敏性。很多研究只是单纯针对植物或动物过敏原进行分类,但是并没有对所有的食物过敏原进行系统性的分类分析。本研究从致敏性蛋白结构数据库SDAP(Structural Database of Allergenic Proteins)中获得已知食品过敏原列表,并将这些食品过敏原在AllFam数据库中进行过敏原家族整理分类,从食品中主要致敏蛋白质的结构和功能出发,分析食品过敏原的家族特异性,并对食品致敏原进行分类。同时,采用DNAStar分析食物过敏原的特定抗原性。对所有
Bioinformatics tools can be used to classify proteins based on the three-dimensional structure of proteins and similar amino acid sequences, and the potential allergenicity of proteins can be predicted by analyzing the properties of various types of proteins. Many studies have simply classified plant or animal allergens but did not systematically classify all food allergens. In this study, a list of known food allergens was obtained from the Structural Database of Allergenic Proteins (SDAP) database. Allergens were classified in the AllFam database for allergen families. The main allergenic proteins Based on the structure and function of the food allergens, we analyzed the familial specificity of food allergens and classified food allergens. At the same time, DNAStar was used to analyze the specific antigenicity of food allergens. For all