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目的探讨T2DM患者合并甲状腺功能减退(下称“甲减”)的相关因素。方法选取T2DM合并甲减患者100例作为甲减组,甲状腺功能正常的T2DM患者1031例作为T2DM组,检测两组的一般资料及生化指标。结果甲减组年龄[(61.03±10.93)vs(54.89±11.17)岁]、女性比例[67(67.0%)vs 430(41.7%)]、T2DM病程[10.0(4.0,16.0)vs 6.0(2.0,11.0)年]、SBP[(141.55±20.24)vs(136.52±19.46)mmHg]、促甲状腺激素(TSH)[5.88(4.94,9.26)vs 1.40(0.97,2.02)μU/ml]、胰岛素治疗者比例[61(61.0%)vs 456(44.2%)]和甲状腺过氧化物酶抗体(TPO-Ab)阳性率[45(45.0%)vs111(10.8%)]较T2DM组高,DBP[(79.45±10.15)vs(82.16±11.14)mmHg]、HbA1c[7.9(6.9,9.3)%vs 8.4(7.2,10.0)%]、游离三碘甲状腺原氨酸(FT3)[3.94(3.39,4.32)vs 4.43(4.01,4.86)pmol/L]、游离甲状腺素(FT4)[(13.97±3.22)vs(17.04±2.13)pmol/L]和吸烟者比例[14(14.0%)vs 363(35.2%)]较T2DM组低(P<0.05或P<0.01)。Logistic多元回归分析结果显示,年龄、吸烟、胰岛素治疗和TPO-Ab是T2DM患者合并甲减的影响因素。结论年龄、吸烟和TPO-Ab是T2DM患者合并甲减的影响因素,胰岛素治疗可能与T2DM患者合并甲减有关。
Objective To investigate the related factors of T2DM with hypothyroidism (“hypothyroidism”). Methods Totally 100 T2DM patients with hypothyroidism were selected as hypothyroidism group and 1031 T2DM patients with normal thyroid function as T2DM group. The general data and biochemical indexes of the two groups were detected. Results The age of the hypothyroidism group [(61.03 ± 10.93 vs 54.89 ± 11.17) years and female ratio (67.0 67.0%) vs 430 (41.7% 11.0) years], SBP [(141.55 ± 20.24) vs (136.52 ± 19.46) mmHg], thyrotropin (TSH) [5.88 (4.94,9.26) vs 1.40 (0.97, 2.02) μU / ml] (45.0%) vs111 (10.8%) were higher than those in T2DM group [(61.0%) vs 456 (44.2%) and TPO-Ab positive rate (82.16 ± 11.14) mmHg], HbA1c [7.9 (6.9,9.3)% vs 8.4 (7.2,10.0)%], free triiodothyronine (FT3) [3.94 (3.39,4.32) vs 4.43 , 4.86) pmol / L, FT4 (13.97 ± 3.22 vs 17.04 ± 2.13 pmol / L) and smoker (14.0% vs. 363.35%, respectively) Low (P <0.05 or P <0.01). Logistic multiple regression analysis showed that age, smoking, insulin therapy and TPO-Ab were the influencing factors of hypothyroidism in T2DM patients. Conclusion Age, smoking and TPO-Ab are the influencing factors of hypothyroidism in T2DM patients. Insulin therapy may be related to hypothyroidism in T2DM patients.