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目的探究乳酸脱氧酶(LDH)、中性粒细胞CD_(64)和脑脊液β2微球蛋白(CSFβ2-MG)对小儿中枢神经系统感染的诊断价值。方法选取医院2013年5月-2017年5月医院接受治疗的60例小儿中枢神经系统感染患者作为研究对象,根据病原不同分为细菌感染组30例和病毒感染组30例,选择同期30例无小儿中枢神经系统感染患者为对照组,比较三组患儿中性粒细胞CD_(64)、乳酸脱氢酶和脑脊液β2微球蛋白含量及阳性率。结果病毒感染组与细菌感染组患者LDH、中性粒细胞CD_(64)和脑脊液β2微球蛋白含量均高于对照组,而细菌感染组患者LDH(281.3±45.6)U/L、中性粒细胞CD_(64)(1.63±0.52)mg/L和脑脊液β2微球蛋白含量(3.03±1.02)mg/L高于病毒感染组患者(53.3±8.5)U/L、(1.05±0.35)mg/L、(2.45±0.61)mg/L,三组比较差异有统计学意义(P<0.05);病毒感染组患者LDH阳性率10.00%,细菌感染组为70.00%,两组比较差异有统计学意义(P<0.05);病毒感染组患者中性粒细胞CD_(64)阳性率10.00%,细菌感染组患者66.67%,两组比较差异有统计学意义(P<0.05);病毒感染组患者CSFβ2-MG阳性率6.67%,细菌感染组患者83.30%,两组比较差异有统计学意义(P<0.05);LDH+中性粒细胞CD_(64)+CSFβ2-MG敏感度为99%、准确度为97%高于LDH及中性粒细胞CD_(64)的敏感度和准确度。结论乳酸脱氢酶、中性粒细胞CD_(64)以及脑脊液β2微球蛋白检测可作为鉴别小儿中枢神经系统感染的重要指标,具有积极的临床意义。
Objective To investigate the diagnostic value of lactate dehydrogenase (LDH), neutrophil CD_ (64) and cerebrospinal fluid β2 microglobulin (CSFβ2-MG) in children with central nervous system infection. Methods A total of 60 children with CNS infection admitted to the hospital from May 2013 to May 2017 were selected as the study subjects. According to the different pathogens, 30 patients were divided into bacterial infection group and 30 viral infection group, 30 patients in the same period Children with central nervous system infection in the control group, compared the three groups of children with neutrophil CD_ (64), lactate dehydrogenase and cerebrospinal fluid β2 microglobulin content and positive rate. Results The levels of LDH, neutrophil CD_ (64) and cerebrospinal fluid β2 microglobulin in viral infection group and bacterial infection group were higher than those in control group, while those in bacterial infection group were 281.3 ± 45.6 U / L, The levels of CD_ (64) (1.63 ± 0.52) mg / L and cerebrospinal fluid β2 microglobulin (3.03 ± 1.02) mg / L were significantly higher than those in the virus infected group (53.3 ± 8.5) L, (2.45 ± 0.61) mg / L, respectively. There was a significant difference between the three groups (P <0.05). The positive rate of LDH in the virus infected group was 10.00%, and that in the bacterial infection group was 70.00% (P <0.05). The positive rate of neutrophil CD_ (64) in infected group was 10.00%, and that in bacterial infection group was 66.67%. There was significant difference between the two groups (P <0.05) MG positive rate of 6.67%, bacterial infection 83.30%, the difference between the two groups was statistically significant (P <0.05); LDH + neutrophil CD_ (64) + CSFβ2-MG sensitivity was 99%, the accuracy of 97 % Higher than LDH and neutrophil CD_ (64) sensitivity and accuracy. Conclusion The detection of lactate dehydrogenase, neutrophil CD_ (64) and cerebrospinal fluid β2 microglobulin can be used as an important index to identify central nervous system infection in children and has a positive clinical significance.