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第Ⅱ、Ⅴ、Ⅸ、和Ⅹ凝血因子的前体系在肝内合成,而这些前体的激活均需维生索K(V-K),凝血酶原时间(PT)为其检测指标。当PT异常时,有可能反映因实质性肝病(PLD)所致的前体合成障碍或因梗阻性肝病(OLD)所致的V-K缺乏。一致认为检测PT及其对V-K的反应有助于OLD与PLD的鉴别。然而,在OLD时因V-K缺乏而影响到PT所需的时间则尚未确定。为了弄清与PLD和OLD相关的PT变化,作者应用四氯化碳(2ml/kg)使大鼠发生PLD,通过结扎胆管使之发生OLD,并于PLD形成后36小时,OLD形成后3周检测凝血参数,结果如下,并与PLD或手术证实的OLD病人(有黄疸在3周以内)的资料比较(见表)。
The precursors to â ... ¢ â ..., â ... ¡, â ... ¡and â ... ¡coagulation factors in the liver synthesis, and the activation of these precursors are required cable K (V-K), prothrombin time (PT) as a test indicator. When the PT is abnormal, it is possible to reflect precursor synthesis disorders due to essential liver disease (PLD) or V-deficiency due to obstructive liver disease (OLD). It is agreed that the detection of PT and its response to V-K contributes to the identification of OLD and PLD. However, the time required to affect PT due to V-K deficiency at OLD has not been established. To clarify the PT changes associated with PLD and OLD, the authors developed PLD in rats using carbon tetrachloride (2 ml / kg), OLD by ligation of the bile duct, and 36 h after PLD formation, 3 weeks after OLD formation Coagulation parameters were measured and the results were as follows and compared with data from PLD or surgically-confirmed OLD patients with jaundice within 3 weeks (see table).