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目的：探讨在分化型甲状腺癌中Ｐ２１ｒａｓ阳性表达的相关因素，为推测预后提供依据并指导治疗方案。方法：用免疫组化ＬＳＡＢ法对３６例分化型甲状腺癌、４例非典型增生、４例正常组织Ｐ２１ｒａｓ表达进行研究。结果：甲状腺癌过度表达，乳头状癌和滤泡癌阳性率分别为９０％、５６％，二者比较有显著差异Ｐ＜００５；非典型增生部分呈弱阳性表达。表达率及强度与转移、肿瘤大小、年龄、病程都无关，而与肿瘤分级有关。结论：强阳性表达可作为评估预后的指征。
Objective: To investigate the related factors of P21ras positive expression in differentiated thyroid cancer, and provide basis for predicting prognosis and guide treatment plan. METHODS: The expression of P21ras in 36 cases of differentiated thyroid cancer, 4 cases of atypical hyperplasia, and 4 cases of normal tissues was studied by immunohistochemical LSAB method. RESULTS: Overexpression of thyroid carcinoma, positive rate of papillary carcinoma and follicular carcinoma were 90% and 56%, respectively. There was a significant difference between the two groups (P<0.05). The atypical hyperplasia showed weak positive expression. The expression rate and intensity were not related to metastasis, tumor size, age, and course of disease, but related to tumor grade. Conclusion: Strong positive expression can be used as an indicator of prognosis.