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目的:探讨赖氨葡锌颗粒联合鞣酸蛋白酵母散治疗小儿急性腹泻的效果。方法:选取2017年9月至2018年8月郑州大学附属儿童医院消化内科收治的84例小儿急性腹泻患儿，男45例，女39例，年龄(3.43±1.54)岁，年龄范围为1～12岁。采用随机数表法将患儿随机分为联合治疗组和单纯治疗组，每组42例。单纯治疗组采用鞣酸蛋白酵母散治疗，联合治疗组在单纯治疗组基础上辅以赖氨葡锌颗粒治疗。观察比较两组患儿的临床治疗效果、康复时间及病情复发情况。结果:联合治疗组临床有效率92.9%(39/42)高于单纯治疗组的76.2%(32/42)，差异有统计学意义(n P<0.05)。联合治疗组腹泻恢复正常时间[(2.17±0.28)d]、呕吐消失时间[(1.31±0.35)d]、体温恢复时间[(1.25±0.42)d]及住院时间[(4.68±0.35)d]均短于单纯治疗组[(5.83±0.31)d、(3.49±0.39)d、(3.58±0.37)d、(7.92±0.38)d]，差异有统计学意义(n P<0.05)。联合治疗组治疗后随访1、3个月的病情复发率[0、4.8%(2/42)]均低于单纯治疗组[11.9%(5/42)、21.4%(9/42)]，差异有统计学意义(n P<0.05)。两组均未发生严重的药物不良反应，且未发生锌中毒症状，并经心电图、肝肾功能、血尿常规检查无异常改变。n 结论:对小儿急性腹泻患儿应用赖氨葡锌颗粒联合鞣酸蛋白酵母散的治疗效果显著，有助于促进患儿早期康复，减少病情反复复发，且治疗安全可靠，值得在临床上推广应用。“,”Objective:To investigate the efficacy of lysine zinc zinc granules combined with tannin protein yeast powder in the treatment of acute diarrhea in children.Methods:A total of 84 children with acute diarrhea treated in the department of Gastroenterology of Children′s Hospital of Zhengzhou University from September 2017 to August 2018.There were 45 males and 39 females, aged(3.43±1.54)years old, ranging from 1 to 12 years old.The patients were randomly divided into the combined treatment group and the single treatment group, with 42 patients in each group.The single treatment group of patients were treated with tannic acid and yeast powder, and the combined treatment group of patients were supplemented with lysine and zinc granules.The clinical efficacy, rehabilitation time and recurrence of the two groups were compared.Results:The total clinical response rate of the combined treatment group was 92.9%(39/42), which was higher than that of the single treatment group(76.2%, 32/42), and the difference was statistically significant(n P<0.05). The recovery time of diarrhea[(2.17±0.28)days], the disappearance time of vomiting[(1.31±0.35)days], the recovery time of body temperature[(1.25±0.42)days]and the length of stay[(4.68±0.35)days]in the combined treatment group were all shorter than those in the single treatment group[(5.83±0.31)days, (3.49±0.39)days, (3.58±0.37)days, (7.92±0.38)days], and the differences were statistically significant(n P<0.05). The relapse rate of the combined treatment group[0, 4.8%(2/42)]was lower than that of the single treatment group[11.9%(5/42), 21.4%(9/42)]after 1 and 3 months of follow-up, and the difference was statistically significant(n P<0.05). No serious adverse drug reactions occurred in the two groups, and no symptoms of zinc poisoning occurred, and no abnormal changes were observed by electrocardiogram, liver and kidney function, and routine hematuria examination.n Conclusion:For children with acute diarrhea, the application of lysine and zinc granules combined with tannin protein yeast powder has a significant effect, which helps to promote early recovery of children, reduce repeated recurrence, and the treatment is safe and reliable, which is worth of clinical promotion.