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用9周~39周引产胎儿标本72例,取右耳廓石蜡切片,HE染色,光镜观察其皮肤及附属器的组织发生。观察结果表明,表皮:9周时为多层细胞,13周表皮表层细胞变扁平,21周出现颗粒层,24周出现角化层,30周后其结构逐渐与成人近似;毛发:9周在耳尖和耳垂见少量毛芽,13周毛球和毛根形成,14周毛干和毛乳头形成,16周结构较典型;皮脂腺:14周在毛囊上部出现皮脂腺芽,22周发达;汗腺:14周出现汗腺芽,24周在耳尖部出现导管和腺泡,26周见肌上皮细胞。对胎儿耳廓皮肤及附属器的组织发生进行了讨论。
Seventy-two fetuses with induced abortion were collected from 9 weeks to 39 weeks, paraffin sections of the right auricle were obtained and stained with hematoxylin-eosin (HE). The appearance of skin and appendages was observed with light microscope. The results showed that the epidermis was a multilayered cell at 9 weeks, and the epidermis cells became flattened at 13 weeks with granular layer at 21 weeks and keratinized layer at 24 weeks. A small amount of hair buds were observed in the ear and ear lobes, hair ball and hair root formed at 13 weeks, hair shaft and dermal papilla formed at 14 weeks, and the structure of 16 weeks was typical. Sebaceous gland: sebaceous gland bud emerged at upper part of hair follicle in 14 weeks, developed at 22 weeks; 24 weeks in the tip of the ear catheter and acinar, 26 weeks to see myoepithelial cells. The histological appearance of the fetal auricle skin and appendages is discussed.