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目的 了解不同行为类型的医学生应激前后血浆 CN含量变化 ,为探讨心理行为因素引发冠心病中介机制的研究提供前瞻性资料。方法 用前瞻性方法研究解剖学期终考试对不同行为类型的医学生血浆环核苷酸 (CN)含量的影响。结果 应激前 ,TABP医学生血浆 c AMP含量显著高于 TBBP医学生 (P <0 .0 0 1) ;应激后 ,TABP和 TBBP医学生血浆 c AMP均显著下降 (P <0 .0 0 1) ,其下降程度前者明显大于后者 ,(P <0 .0 0 1) ;血浆 c GMP含量均下降 ,但无差异 (P >0 .0 5 ) ,c AMP/c GMP比值 TABP和 TBBP两者均显著下降 (P <0 .0 0 0 1)。但下降程度 TABP和 TBBP之间无显著差异 (P >0 .0 5 )。结论 考试应激对医生生血浆 c AMP含量的影响 TABP者显著大于 TBBP者
Objective To understand the changes of plasma CN levels in medical students with different types of behavior before and after stress, and to provide prospective data for investigating the mechanism of mental behavior induced coronary heart disease. Methods A prospective study was conducted to investigate the effect of final anatomy examinations on plasma cyclic nucleotide (CN) levels in medical students with different types of behavior. Results Before stress, plasma cAMP levels in TABP medical students were significantly higher than those in TBBP medical students (P <0.01). After stress, plasma cAMP in TABP and TBBP decreased significantly (P <0.05) 1). The former was significantly higher than the latter (P <0.01). Plasma cGMP levels were decreased but no difference (P> 0.05). The ratio of cAMP / c GMP to TABP and TBBP Both were significantly decreased (P <0.0001). However, there was no significant difference in the degree of decline between TABP and TBBP (P> 0.05). Conclusion The impact of test stress on plasma cAMP content in doctors was significantly higher than that of TBBP in those with TABP