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Noninvasive ultrasound is a more effective strategy for on-demand drug delivery of polymeric nanoparticles than many other stimuli.However,the preparation of ultrasound-responsive homopolymer nanoparticles is still very challenging.In this study,we disclose the regulating factors of ultrasound responsiveness of homopolymer nanoparticles and the disaggregation behavior of homopolymer nanoparticle aggregates.Homopolymer nanoparticles such as vesicles and large compound micelles (LCMs) are self-assembled from poly(methoxyethyl methacrylate)(PMEMA) and poly(amic acid) (PAA),respectively.The ultrasound responsiveness of PAA vesicles at metastable state could be regulated by tuning the self-assembly temperature (Ts),and was optimized when Ts is around the glass transition temperature (Tg) of PAA.However,the PMEMA LCMs did not respond to ultrasound as they are at stable state.On the other hand,poly(2-(2-ethoxyethoxy)ethyl acrylate) (PEEA) could self-assemble into vesicle aggregates or complex micelle aggregates,which were dissociated upon sonication.Overall,the above findings provide us with a fresh insight for designing ultrasound-responsive polymeric nanoparticles.