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糖肽类抗生素替考拉宁的分子结构与万古霉素相似 ,在治疗对青霉素或头孢菌素耐药的革兰阳性菌如MRSA和肠球菌感染方面优于万古霉素。其在临床使用中的不良反应包括药物热 ,瘙痒 ,皮疹 ,局部疼痛 ,寒战 ,恶心或呕吐 ,听觉下降 ,肝功能异常 ,肾毒性 ,血液学异常 (中性粒细胞及血小板减少 )。但各种不良反应类型及发病率较万古霉素低 ,因此在疗效和用药安全性方面替考拉宁比万古霉素更具优势。
The molecular structure of the glycopeptide antibiotic teicoplanin is similar to that of vancomycin and is superior to vancomycin in the treatment of penicillin or cephalosporin-resistant gram-positive bacteria such as MRSA and enterococcal infections. Adverse effects in clinical use include drug fever, pruritus, rash, local pain, chills, nausea or vomiting, hearing loss, abnormal liver function, nephrotoxicity, abnormal hematological (neutrophil and thrombocytopenia). However, the incidence of various types of adverse reactions and the incidence of vancomycin is low, so the efficacy and safety of the drug than teicoplanin than vancomycin more advantages.