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一、因子的活性和免疫反应混合淋巴细胞培养的上清液可刺激提纯的B细胞群对异种红细胞产生抗体反应,这表明辅助性T细胞(T_H)的功能是由可溶性因子介导的。这种因子的活性既不是抗原特异的,也不受MHC限制。随后又发现有两种不同类型的T_H替代因子,既抗原特异的和非抗原特异的因子。非抗原特异性因子在原代淋巴细胞培养中用抗原、同种异型抗原或T细胞分裂素刺激后很容易测到。而产生抗原特异因子则要应用几个步骤:反应性淋
First, the factor activity and immune response Mixed lymphocyte culture supernatant can stimulate purified B cell population on the red blood cells to produce antibody responses, suggesting that the function of helper T cells (T_H) is mediated by soluble factors. The activity of this factor is neither antigen specific nor MHC restricted. It was subsequently found that there are two different types of T_H replacement factors, both antigen-specific and non-antigen specific. Non-antigen specific factors are readily detectable in primary lymphocyte cultures stimulated with antigen, alloantigen or T-cell mitogen. The production of antigen-specific factors will have to apply several steps: reactive shower