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目的探讨中药治疗急性出血坏死性胰腺炎（ＡＨＮＰ）的病理与血液流变学改变．方法应用血液流变学的检测方法，观察兔ＡＨＮＰ时通过活血化瘀中药（丹参，红花，木香，元胡，大青叶，栀子，鱼腥草，二芍，厚朴，枳壳及大黄）腹腔灌注治疗后血液流变学的各种变化．将兔分为ＡＨＮＰ模型组（ｎ＝２０）、中药腹腔灌注组（ｎ＝１９）及对照组（ｎ＝１１）．ＡＨＮＰ模型组和中药腹腔灌注组分别于２，６，２４和４８ｈ取血做血液流变学检查．同时作病理学观察比较．结果中药腹腔灌注组２４ｈ全血还原粘度、血小板聚集性降低．全血还原粘度为４２３６±２７７，血小板聚集性为４２５±３１５，而ＡＨＮＰ模型组中２４ｈ全血还原粘度为５７７±９５２，血小板聚集性为１８１２±７２６（Ｐ＜００５）．中药腹腔灌注组４８ｈ全血粘度、全血还原粘度、血小板聚集性明显降低，全血粘度为１３８０±４６８，全血还原粘度为３４７１±１５２５，血小板聚集性为３０８±０５５，而ＡＨＮＰ模型组４８ｈ全血粘度为３０７１±２７９，全血还原粘度为８５４７±７２２，血小板聚集性为２０９３±６０１（Ｐ＜００１）．结论早期应用活血化瘀中药，可以纠正血液流变学的异?
Objective To investigate the pathological and hemorheological changes of acute hemorrhagic necrotizing pancreatitis (AHNP) treated by traditional Chinese medicine. Methods The hemorheology method was used to observe the effect of AHNP on the blood circulation and blood circulation in rabbits by using traditional Chinese medicine (Salvia miltiorrhiza, safflower, woody, Yuanhu, Daqingye, Zhizi, Houttuynia, And rhubarb) Various changes in hemorheology after intraperitoneal perfusion. Rabbits were divided into AHNP model group (n = 20), Chinese medicine peritoneal perfusion group (n = 19) and control group (n = 11). AHNP model group and Chinese medicine peritoneal perfusion group were taken blood at 2,6,24 and 48h blood rheology examination. At the same time for pathological observation and comparison. Results Chinese medicine intraperitoneal perfusion group 24h whole blood reduction viscosity, decreased platelet aggregation. The reduction of whole blood viscosity was 42 36 ± 2 77, platelet aggregation was 4 25 ± 3 15, while 24h ANAP model group reduced viscosity of 57 7 ± 9 52, platelet aggregation was 18 12 ± 726 (P <005). The 48h whole blood viscosity, whole blood viscosity and platelet aggregation decreased significantly in the group of peritoneal perfusion, the whole blood viscosity was 1380 ± 468, the whole blood reduced viscosity was 3471 ± 1525, and the platelet aggregation was 3 08 ± 055, while the AHNP model group 48h whole blood viscosity was 30 71 ± 2 79, the whole blood reduction viscosity was 85 47 ± 7 22, platelet aggregation was 20 93 ± 6 01 (P <001). Conclusion early application of traditional Chinese medicine, blood circulation can correct the different?