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遗传因素是痛风发病的一个重要因素。高尿酸血症和痛风的易感性在全基因组关联研究和Meta的研究中已经有了显著的提高。基因的突变是涉及嘌呤的酶类编码和尿酸产生过多，及细胞过度凋亡和三磷酸腺苷退化的结果。而肾脏尿酸盐的吸收和分泌平衡是决定血清尿酸水平的主要因素，突变所导致的基因功能缺失可引起高尿酸血症与遗传性肾脏疾病。“,”Genetic factor is an important factor in the pathogenesis of gout. Hyperuricemia and gout susceptibility genome-wide association studies and Meta-research have been significantly improved. Gene mutation is the result of purine enzymes encoding genes and excessive uric acid,and the excessive cell apop-tosis and adenosine triphosphate degradation. The balance of absorption and secretion of urate in kidney is a major factor determining the serum concentration of uric acid,and gene mutations caused loss of function may lead to hyperuricemia and hereditary kidney disease.