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目的探讨四联疗法与三联疗法治疗幽门螺杆菌所致胃溃疡的疗效并进行对比分析。方法 100幽门螺杆菌所致胃溃疡患者,通过盲选的方式分为研究组与对照组,每组50例。对照组患者采用三联疗法治疗,研究组患者采用四联疗法治疗,两组患者均持续治疗1个月,观察治疗效果。结果研究组患者治疗总有效率(96.00%)明显高于对照组(76.00%),差异具有统计学意义(P<0.05)。研究组不良反应发生率(8.00%)与对照组(12.00%)比较差异无统计学意义(P>0.05)。研究组患者幽门螺杆菌清除率(88.00%)明显高于对照组(70.00%),差异具有统计学意义(P<0.05)。结论应用四联疗法治疗的临床治疗效果以及幽门螺杆菌清除率均较高,而且发生不良反应的几率较低,值得推广应用。
Objective To investigate the curative effect of quadruple therapy and triple therapy on gastric ulcer caused by Helicobacter pylori and compare the results. Methods 100 patients with gastric ulcer caused by Helicobacter pylori were divided into study group and control group by blind selection, with 50 cases in each group. Patients in the control group were treated with triple therapy. Patients in the study group were treated with quadruple therapy. Patients in both groups were treated continuously for 1 month to observe the therapeutic effect. Results The total effective rate (96.00%) in study group was significantly higher than that in control group (76.00%), the difference was statistically significant (P <0.05). There was no significant difference in the incidence of adverse reactions between the study group (8.00%) and the control group (12.00%) (P> 0.05). The Helicobacter pylori clearance rate (88.00%) in study group was significantly higher than that in control group (70.00%), the difference was statistically significant (P <0.05). Conclusion The curative effect and the clearance rate of Helicobacter pylori in patients treated with quadruple therapy are high, and the incidence of adverse reactions is low, which is worth popularizing and applying.