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目的:研究麦芽纤维对溃疡性结肠炎(UC)小鼠肠道菌群的影响。方法:将40只BALB/c小鼠随机分为正常组、模型组、自然恢复组、对照组(柳氮磺吡啶)和治疗组(麦芽纤维),每组8只。采用细菌培养的方法检测小鼠盲肠内容物中几种常见菌群的数量。结果:UC小鼠肠道内肠杆菌、肠球菌及产气荚膜梭菌数量增加,双歧杆菌和乳酸杆菌数量减少。经麦芽纤维治疗2周后,肠杆菌和肠球菌数量减少,双歧杆菌和乳酸杆菌数量明显增加。结论:麦芽纤维对UC小鼠肠道菌群具有良好的调控作用。
Objective: To study the effect of malt fiber on intestinal flora in mice with ulcerative colitis (UC). Methods: Forty BALB / c mice were randomly divided into normal group, model group, spontaneous recovery group, control group (sulfasalazine) and treatment group (malt fiber). The bacterial culture method was used to detect the amount of several common bacterial colonies in the cecal contents of mice. RESULTS: The numbers of enterobacter enterococci, enterococci and C. perfringens in UC mice increased and the numbers of Bifidobacterium and Lactobacillus decreased. After 2 weeks of malt fiber treatment, the number of Enterobacteriaceae and Enterococcus decreased, and the number of Bifidobacterium and Lactobacillus significantly increased. Conclusion: Malt fiber has a good regulation on intestinal flora of UC mice.