论文部分内容阅读
Ｐ＜０．００１，与组２比较从表６可见，单用消瘤胶囊对小鼠血液白细胞数，胸腺和脾指数均无明显抑制，而阳性对照药环磷酰胺则显著抑制上述三个指标，当联合应用二药时，上述抑制作用减轻，其中胸腺指数和脾指数与单用环磷酰胺比较有明显提高（Ｐ值分别＜０．０５和０．００１）。３．碳粒廓清试验雄性ＩＣＲ纯系小鼠５０只，１８～２３ｓ，随机分为５组，每组１０只，按表７所示连续给药８天，于未次给药后１小时，尾静脉注射胶体碳溶液（１．６％～０．ｌｍｌｌ１０ｓ），分别经１和５分钟取血２０μｌ，加入０．１％Ｎａ２ＣＯ３２ｍｌ中静置６小时，放入７２１分光光度计测ＯＤ值，计算Ｋ值（廓清指数），结果见表７（表略）。从表７可见，对小鼠碳粒廓清率，ＣＴＸ明显抑制而神州消瘤胶囊没有显著效应，联用ＣＴＸ和消瘤胶囊，碳粒廓清率比单用ＣＴＸ虽然有所提高，但统计学上差异无显著意义（Ｐ＞０．０５）。４．小鼠血清溶血素形成试验ＩＣＲ纯系小鼠（雄）５０只，１７～２０ｇ，随机分为５组，每组１０只，给药方案同表７，于给药第３天每鼠腹腔注射１０％ＳＲＢＣ０．２ｍｌ免疫，阳性对照组从免疫次日起给予ＣＴＸｉｇ５天，各组于未次给药后１小时眼眶取血，分离血清，并以生理盐水３０?
P<0.001, compared with group 2, as can be seen from Table 6, the single-use Xiaoliu capsule had no significant inhibition on blood leukocytes, thymus and spleen index of mice, while the positive control drug cyclophosphamide significantly inhibited the above three indicators. When combined use of the two drugs, the above inhibitory effect was reduced, and the thymus index and spleen index were significantly improved compared with cyclophosphamide alone (P values were <0.05 and 0.001, respectively). 3. Fifty male ICR purebred mice were used in the carbon clearance test and were randomly divided into 5 groups with 10 rats in each group. The continuous administration was performed as shown in Table 7 for 8 days. The tail vein was given 1 hour after the administration. Inject colloidal carbon solution (1.6% to 0.lmll10s), take 20μl of blood in 1 and 5 minutes, add 0.1% Na2CO32ml and let stand for 6 hours, add 721 spectrophotometer to measure OD, calculate K value. (clear index), the results are shown in Table 7 (abbreviated). From Table 7, it can be seen that the clearance rate of carbon particles in mice, CTX significantly inhibited and Shenzhou Xiaoliu capsules have no significant effect, combined with CTX and Xiaoliu capsules, the carbon particle clearance rate is improved compared to CTX alone, but statistically There was no significant difference (P>0.05). 4. Mouse serum hemolysin formation test ICR pure mouse (male) 50, 17 ~ 20g, were randomly divided into 5 groups, each group of 10, the dosing scheme is the same as in Table 7, on the third day of dosing every mouse intraperitoneal injection 10% SRBC 0.2ml immunization, the positive control group was given CTXig for 5 days from the next day of immunization. Blood was taken from the eyelids 1 hour after each administration, and the serum was separated and normal saline was used.