美沙芬(dextromethorphan,DMT)是近年来普遍使用的新型镇咳药,此药的代谢物之一羟甲左吗喃(levorphanol,LE)是国际奥委会禁止使用的麻醉镇痛剂,因而DMT也属“相关化合物”而在被禁用之列。已有人从尿中检测出美沙芬的多种代谢物,其中包括本文所研究的代谢物。此药及其代谢物的分析方法有HPLC法、GC法及GC—MS法。本文用GC—MS法建立了分析美沙芬及其代谢物的方法,此方法亦可用于其它禁用药物的分析,方法简便、快速。 As a novel antitussive commonly used in recent years, dextromethorphan (DMT), one of the metabolites of this drug, is a non-use narcotic analgesic administered by the International Olympic Committee. Therefore, DMT It is also a “related compound” and is banned. Various metabolites of methadone have been detected in the urine, including the metabolites studied herein. The drug and its metabolites analysis methods are HPLC method, GC method and GC-MS method. In this paper, GC-MS method was established for the analysis of methadone and its metabolites, this method can also be used for other banned drug analysis, the method is simple and fast.