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目的探讨T2DM合并下肢动脉病变(LEAD)患者25-羟维生素D_3(25-OH-D_3)、血尿酸(SUA)等指标的变化。方法选取于我院内分泌科住院治疗的T2DM患者176例,根据双下肢动脉彩超分为下肢动脉病变组(LEAD,n=100)和单纯T2DM组(Con,n=76),测定25-OH-D_3、SUA、HbA_1c、血脂、24 h尿微量白蛋白(UMalb),比较两组上述指标、年龄、病程和BMI的变化。结果LEAD组年龄、病程、HbA_1 c、TC、24 h UMalb均高于Con组(P<0.05),25-OH-D_3低于Con组[(18.03±1.30)vs(22.32±1.48)ng/ml,P<0.05]。Logistic二元回归分析显示,年龄、病程和HbA_1 c是T2DM合并LEAD的独立危险因素。结论T2DM患者中年龄大、病程长、血脂高、血糖控制差的易合并LEAD,24 h UMalb、SUA、25-OH-D_3与T2DM合并LEAD有相关性。
Objective To investigate the changes of 25-hydroxyvitamin D3 (D-3) and serum uric acid (SUA) in T2DM patients with lower extremity arterial disease (LEAD). Methods A total of 176 T2DM patients hospitalized with endocrinology in our hospital were enrolled in this study. According to the arterial ultrasonography in lower extremities, the patients were divided into two groups: LEAD (n = 100) and T2DM (Con, n = 76) D_3, SUA, HbA_1c, blood lipids, and 24 h urinary albumin (UMalb). The above indexes, age, course of disease and BMI were compared between the two groups. Results The age, course of disease, HbA 1 c, TC and 24 h UMalb in LEAD group were significantly higher than those in Con group (P <0.05), and 25-OH-D 3 was lower than that in Con group [(18.03 ± 1.30) vs (22.32 ± 1.48) ng / ml , P <0.05]. Logistic regression analysis showed that age, duration of disease and HbA 1 c were independent risk factors for T2DM with LEAD. Conclusions There are correlations between LEAD, 24 h UMalb, SUA, 25-OH-D_3 and T2DM with LEAD in T2DM patients, including older age, longer duration of disease, higher serum lipids and poor blood glucose control.