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报告了一种新型的内毒素肠套叠动物模型，并对其发病机理进行了初步探索。结果发现：给小鼠腹腔内注射内毒素，肠套叠诱发率为２３．８％，内毒素最佳剂量是１２ｍｇ／ｋｇ，肠套叠形成高峰时间在６～１２ｈ。内毒素使肠传递时间延长，一氧化氮合成酶抑制剂Ｌ－ＮＡＭＥ降低肠套叠诱发率。实验结果提示：内毒素可诱发肠套叠，其发病机理与肠动力紊乱有关。该动物模型可为研究肠套叠的病因，发病机理及治疗提供帮助。
A new type of endotoxin intussusception animal model was reported and the pathogenesis of it was preliminary explored. The results showed that intraperitoneal injection of endotoxin in mice resulted in a 23.8% incidence of intussusception, an optimal endotoxin dose of 12 mg / kg, and an intussusception time of 6-12 h. Endotoxin prolongs intestinal delivery, and L-NAME, a nitric oxide synthase inhibitor, decreases the incidence of intussusception. The results suggest that: endotoxin can induce intussusception, its pathogenesis and intestinal motility disorders. This animal model can help to understand the etiology, pathogenesis and treatment of intussusception.