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作者首次在泰国使用青蒿琥酯和蒿甲醚治疗耐多种抗疟药的恶性疟原虫。68例成年、男性恶性疟患者,经分组比较了总剂量为200～1200mg的青蒿琥酯的给药途径、不同疗程对疗效的影响及蒿甲醚480mg肌注的治疗效果。结果显示:所有68例病人在治后1～3d临床症状均逐渐消失,清除99%的原虫血症所需时间是18～36h。疗程达5d的口服青蒿琥酯(总剂量600～1200mg)或肌肉注射蒿甲醚的患者,治愈率为90%～100%;用
The authors first used artesunate and artemether in Thailand to treat Plasmodium falciparum, a variety of anti-malarial drugs. Sixty-eight adult male patients with falciparum malaria were divided into groups to compare the route of administration of artesunate at a total dose of 200-1200 mg, the effect of different courses of treatment, and the therapeutic effect of artemether 480 mg intramuscularly. The results showed that all 68 patients died of clinical symptoms 1 to 3d after treatment, and the time required to clear 99% of parasitemia was 18-36h. Treatment of up to 5d oral artesunate (total dose 600 ~ 1200mg) or intramuscular artemether in patients with a cure rate of 90% to 100%; with