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目的:探索慢性阻塞性肺病(COPD)患者呼出气冷凝液(EBC)pH的变化和EBC中CO2对pH的影响。方法:分别对20例COPD患者和健康志愿者用自制EBC收集器收集EBC,将收集的EBC两等份,一份立即测pH值,另一份通氩气后再测pH。结果:①通氩气前后,COPD组pH均低于健康组,通氩气前两组pH分别为(6.72±0.31)、(7.62±0.23),通氩气后为(7.66±0.17)、(8.54±0.19)。②通氩气后,COPD组和对照组pH均显著升高,变异率均较通氩气前小。两组pH变化值与通氩气前pH值均呈负相关(r分别为-0.946,-0.807)。结论:COPD患者EBC pH明显降低。EBC中CO2可以降低EBC pH,为排除CO2对pH的影响,检测EBC pH前需预先除去EBC中的CO2。
Objective: To investigate the changes of pH value of exhaled breath condensate (EBC) and the effect of CO2 on pH in patients with chronic obstructive pulmonary disease (COPD). Methods: EBC was collected from 20 COPD patients and healthy volunteers using homemade EBC collectors. Two equal portions of collected EBC were collected, one was measured immediately and the other was measured with argon gas. Results: ① Before and after argon, the pH of COPD group was lower than that of healthy group. The pH of the two groups were (6.72 ± 0.31) and (7.62 ± 0.23), respectively, and (7.66 ± 0.17) and 8.54 ± 0.19). ② After argon, the pH of COPD group and control group were significantly increased, the rate of mutation was smaller than the previous argon. There was a negative correlation between the pH value of the two groups and the pH value before argon gas (r = -0.946, -0.807, respectively). Conclusion: EBC pH in patients with COPD was significantly lower. EBC in the CO2 can reduce the EBC pH, in order to exclude the impact of CO2 on the pH, EBC in the detection of EBC before the need to remove the CO2 in the EBC.