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目的：探讨儿童肾病综合征（NS）患者血浆D二聚体（DD）水平变化的临床意义。方法：采用ELISA法检测28例NS患儿（其中单纯型16例，肾炎型12 例）血浆DD含量及末梢血血小板计数（PLT），并与正常对照组进行比较，单纯型与肾炎型进行比较。结果：NS患儿的DD及PLT值均明显高于对照组，两组间有显著性差异（P<0．01）；肾炎型NS的DD水平也明显高于单纯型（P<0．05）。结论：血浆DD水平增高提示NS患儿有高凝状态，且与病情严重程度平行。因此，DD的检测对儿童NS的临床诊断及病情的判断具有一定的指导意义。
Objective: To investigate the clinical significance of plasma D dimer (DD) level in children with nephrotic syndrome (NS). Methods: The serum DD levels and peripheral blood platelet count (PLT) were measured in 28 children with NS (including 16 in simple type and 12 in nephritis type) by ELISA. Compared with the normal control group, the levels of plasma DD and PLT were compared . Results: The DD and PLT values of children with NS were significantly higher than those of the control group, with significant difference between the two groups (P <0.01). The DD level of nephritis NS was also significantly higher than that of the simple type ). Conclusion: Increased plasma levels of DD suggest a hypercoagulable state in children with NS and parallel to the severity of the disease. Therefore, the detection of DD in children with clinical diagnosis of NS and the judgment of the disease has some guidance.