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对35例手术切除的胃癌,电镜下观察其粘液分泌活动,另6例胃镜活检标本行电镜水平的胞嘧啶单核苷酸酶(CMPase)反应。粘液颗粒在高尔基复合体处形成。具有正常极性的瘤细胞,粘液颗粒以外倾方式把内容物排到细胞游离面,较少见情况下,也可排到细胞内微囊或周围的间质中。有时粘液颗粒和初级溶酶体结合或被包绕在自噬体内,最后被溶酶体酶消化(粒溶,crinophagy)。此现象由于粘液颗粒内显示CMPase活性而得到确证。胃癌细胞的粒溶在文献上未曾提及。Resau在体外短期培养的胰组织中发现酶原颗粒的粒溶,说明此过程也可出现在外分泌细胞。苗氏以组化方法在粘液细胞癌细胞内发现酸性磷酸酶和β—葡萄糖醛酸酶活性均较高,间接证实我们的发现。
Thirty-five cases of surgically resected gastric cancer were observed under electron microscope for mucus secretion activity. Six other endoscopic biopsy specimens underwent electron microscopy with a cytosine mononucleotidylase (CMPase) response. Mucus particles form at the Golgi complex. In tumor cells with normal polarity, mucus particles can be discharged to the free surface of the cell in an undulating manner. In rare cases, they can also be discharged into the intracellular microcapsules or the surrounding interstitium. Sometimes mucus particles bind to the primary lysosome or are surrounded by autophagosomes and are finally digested by lysosomal enzymes (crinophagy). This phenomenon was confirmed due to the presence of CMPase activity within the mucus particles. The lysis of gastric cancer cells has not been mentioned in the literature. Resau found granulysing of zymogen granules in short-term cultured pancreatic tissue, indicating that this process can also occur in exocrine cells. Miao’s histochemical method showed high activity of acid phosphatase and β-glucuronidase in mucinous cell carcinoma, indirectly confirming our findings.