丁酸是食物纤维在结肠腔内经微生物酵解生成的短链脂肪酸,是结肠黏膜细胞的主要能量来源,对于维持细胞的分化和结肠上皮的完整性有重要作用。众多体内外实验表明,丁酸可抑制癌细胞株的生长,促进癌细胞的分化,通过多种途径诱导肿瘤细胞发生凋亡。本文综述了丁酸对肿瘤细胞增殖的影响。 Butyric acid, a short-chain fatty acid produced by microbial digestion of food fibers in the colon lumen, is a major source of energy for colonic mucosal cells and plays an important role in maintaining cell differentiation and the integrity of the colonic epithelium. Numerous in vitro and in vivo experiments show that butyric acid can inhibit the growth of cancer cell lines, promote the differentiation of cancer cells and induce the apoptosis of tumor cells through a variety of ways. This article reviews the effects of butyric acid on tumor cell proliferation.