在寻找低毒的腐草菌素过程中,日本东京微生物化学研究所的梅泽滨夫博士从轮状链霉菌分离得到一组糖肽类抗癌抗生素——博莱霉素类(Bleomycins)。从发酵液经IRC—50层析提取的博莱霉素是一组含铜的混合物,经Sephedex G—25层析纯化。通过纸层析可将博莱霉素分成A,B两大类。A、B两大类经CM—Sephedex层析分成13个以上的组分。国外临床应用 In the search for low-toxic sauciphalin, Dr. Meyersenoff, of the Tokyo Institute of Microbiology, Japan, isolated a group of glycopeptide antibiotics, Bleomycins, from Streptomyces sp. The bleomycin extracted from the fermentation broth by IRC-50 chromatography is a copper-containing mixture purified by Sephedex G-25 chromatography. Bleomycin can be divided into two major classes A and B by paper chromatography. The two major classes of A and B were separated into 13 or more components by CM-Sephedex chromatography. Foreign clinical application