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目的 观察甲磺酸左氧氟沙星对耐青霉素肺炎链球菌 (PRSP)的药敏及疗效。方法 对 6株临床分离的耐青霉素肺炎链球菌 ,采用E test方法 ,测定甲磺酸左氧氟沙星等 6种抗生素的抗菌活性。同时观察甲磺酸左氧氟沙星单药治疗PRSP临床疗效及不良反应。结果 6株PRSP均为低耐药菌株 ,对甲磺酸左氧氟沙星敏感。 6例患者经治疗后 ,5例痊愈 ,1例显效 ,无明显副反应发生。结论 甲磺酸左氧氟沙星可有效治疗耐青霉素肺炎链球菌性肺炎。
Objective To observe the drug sensitivity and efficacy of levofloxacin mesylate against penicillin-resistant Streptococcus pneumoniae (PRSP). Methods Six strains of penicillin-resistant Streptococcus pneumoniae isolated from clinical isolates were tested for the antibacterial activity of six antibiotics, levofloxacin mesylate, by E test. At the same time, we observed the clinical efficacy and adverse reactions of levofloxacin mesylate monotherapy in the treatment of PRSP. Results All six PRSP strains were low resistant and sensitive to levofloxacin mesylate. After the treatment of 6 patients, 5 patients recovered, 1 was markedly effective, no obvious side effects. Conclusion Levofloxacin mesylate can effectively treat penicillin-resistant pneumococcal pneumonia.