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目的研究缺血性脑卒中患者DVT的危险因素,探讨深静脉血栓形成患者TNF-α、IL-6、IL-10的水平变化及临床意义。方法①统计缺血性脑卒中后DVT患者DVT的发生部位和并发症。②比较两组股静脉置管史以及血浆纤维蛋白原浓度。③测定血清TNF-α、IL-6、IL-10的浓度。结果①有高血压、糖尿病、高脂血症、肺部感染、股静脉置管的缺血性脑卒中患者发生DVT的危险较高。②缺血性脑卒中后DVT组和对照组血浆纤维蛋白原水平及血清TNF-α、IL-6、IL-10相比有统计学意义。结论①高血压、糖尿病、高脂血症、肺部感染、血浆纤维蛋白原水平高、股静脉置管可能是缺血性脑卒中后DVT的危险因素。②促炎症细胞因子和抗炎症细胞因子在DVT中相互影响,共同参与了DVT的发生和发展。
Objective To study the risk factors of DVT in patients with ischemic stroke and to explore the changes and clinical significance of TNF-α, IL-6 and IL-10 in patients with deep vein thrombosis. Methods ①The incidence of DVT and its complications in DVT patients after ischemic stroke were calculated. ② Comparison of two sets of femoral vein catheterization history and plasma fibrinogen concentration. ③ determination of serum TNF-α, IL-6, IL-10 concentration. Results ① In patients with ischemic stroke who had hypertension, diabetes mellitus, hyperlipidemia, pulmonary infection and femoral vein catheterization, the risk of developing DVT was high. ② The levels of plasma fibrinogen and serum TNF-α, IL-6 and IL-10 in DVT group and control group after ischemic stroke were statistically significant. Conclusion ① Hypertension, diabetes, hyperlipidemia, pulmonary infection, high plasma fibrinogen level and femoral vein catheterization may be risk factors of DVT after ischemic stroke. ② proinflammatory cytokines and anti-inflammatory cytokines in DVT mutual influence, participate in the occurrence and development of DVT.