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目的观察脂蟾毒配基对人宫颈癌Hela裸鼠移植瘤生长的抑制作用。方法于给药前、给药期间(15d)及停药期间(6d)每3d测量肿瘤的长径及短径,并计算近似瘤体积,停药第6天取瘤称重并进行病理学观察。结果①高剂量脂蟾毒配基(15mg/kg)有较强的急性神经毒性。②脂蟾毒配基对荷瘤鼠体重无明显影响。③高剂量脂蟾毒配基(15mg/kg)对人宫颈癌Hela裸鼠移植瘤生长有明显的抑制作用,停药后没有明显的后续抑制作用,15mg/kg的脂蟾毒配基与5mg/kg平阳霉素对肿瘤增长的抑瘤强度相当。④脂蟾毒配基未发现明显的近期毒性。结论脂蟾毒配基对裸鼠的Hela宫颈癌移植瘤有明显的抑瘤作用,脂蟾毒配基是中药蟾酥抗癌的重要成分,但也发现该化合物有明显的急性神经毒性,进一步开发需要慎重。
Objective To observe the inhibitory effect of dietary toadin on the growth of human cervical carcinoma Hela transplanted tumor in nude mice. Methods Before and after administration (15d) and withdrawal (6d), the major and minor diameters of tumors were measured every 3d and the approximate tumor volume was calculated. On the 6th day, the tumors were weighed and pathologically observed . Results ① high-dose fat toad base (15mg / kg) has a strong acute neurotoxicity. ② fat toad poisoning on the weight of tumor-bearing mice had no significant effect. (3) High dose of ADR (15 mg / kg) significantly inhibited the growth of human cervical carcinoma Hela transplanted tumor in nude mice. There was no obvious follow-up inhibition after stopping drug administration. The 15 mg / kg ADR / kg Pingyangmycin on the tumor growth of tumor growth intensity quite. ④ fat toad toxic ligand did not find significant recent toxicity. Conclusions Balbofloxacin has a significant anti-tumor effect on Hela cervical carcinoma xenografts in nude mice. Adriamycin is an important component of anticancer drug of Toadstool, but it has also been found that the compound has obvious acute neurotoxicity and further development Need careful.