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髓样分化蛋白-2(MD-2)是Toll样受体与脂多糖(LPS)联系的桥梁,作为天然免疫识别的重要调控分子,在脂多糖信号转导过程中扮演重要角色,可能成为炎症性疾病治疗的“新靶点”。现就MD-2的结构分析、相关机制及治疗潜能等作一综述。
MD-2 is a bridge between Toll-like receptors and lipopolysaccharide (LPS). As a key regulator of innate immune recognition, MD-2 plays an important role in the signal transduction of lipopolysaccharides and may be an inflammation The “new target” for the treatment of sexually transmitted diseases. Now on the structural analysis of MD-2, related mechanisms and therapeutic potential for a review.