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目的 :探讨急性脑梗死溶栓治疗过程中血浆D 二聚体变化情况 ,寻找溶栓疗效判断的实验室指标。方法 :用ELISA法定量检测 2 1例急性脑梗死早期溶栓治疗患者不同时间血浆D 二聚体含量。结果 :溶栓后 1小时、6小时D 二聚体水平明显升高 ,和溶栓前比较有显著差异 (P <0 .0 0 1、P <0 .0 5 ) ,2 4小时下降至溶栓前水平 ,48小时和治疗前比明显下降 ,和溶栓前比较有极显著性差异 (P =0 .0 0 1)。D 二聚体的变化情况与神经功能恢复同步。结论 :血浆D 二聚体测定可作为急性脑梗死溶栓治疗疗效判断的实验室指标。
Objective: To investigate the changes of plasma D-dimer during thrombolytic therapy in acute cerebral infarction and to find the laboratory indexes for judging the therapeutic effect of thrombolytic therapy. Methods: Serum D-dimer levels of 21 patients with acute cerebral infarction treated with thrombolysis were measured by ELISA. Results: The level of D dimer at 6 hours after thrombolysis was significantly higher than that before thrombolysis (P <0. 01, P <0. 05), and decreased to dissolubility at 24 hours Pre-suppository level, 48 hours and before treatment decreased significantly compared with before thrombolysis there was a very significant difference (P = 0.010). D dimer changes in synchronization with neurological recovery. Conclusion: Plasma D dimer assay can be used as a laboratory index to judge the therapeutic effect of thrombolysis in acute cerebral infarction.