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氨茶碱目前仍是治疗急、慢性哮喘及其他气道阻塞性疾病的主要药物之一,从1921年使用至今已有近70年历史、60年代初曾报导儿童使用本品后急性中毒及死亡,一度降低了使用率,70年代随着茶碱药效学和药动学机理的逐步阐明,使用又逐步增加。目前,虽然治疗哮喘药物很多,氨茶碱仍为临床上首选药物。本品治疗血浓度范围窄,个体差异大,国外已报道影响氨茶碱分布的因素很多,如:疾病状态、合并用药、年龄、饮食、吸烟、妊娠、服药时间等,目前,国
Aminophylline is still one of the main drugs for the treatment of acute and chronic asthma and other airway obstructive diseases. Since its use in 1921, it has been nearly 70 years old. In the early 1960s, acute poisoning and death were reported in children after using this product , Once reduced the rate of use, with the gradual elucidation of theophylline pharmacodynamics and pharmacokinetics in the 1970s, the use gradually increased. At present, although a lot of drugs for the treatment of asthma, aminophylline is still clinically preferred drug. This product is narrow range of blood concentrations for treatment, individual differences, foreign countries have reported many factors that affect the distribution of aminophylline, such as: disease status, combined medication, age, diet, smoking, pregnancy, medication time, at present,