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目的评价联合黛力新或氟西汀治疗功能性消化不良(FD)的疗效。方法将125例FD患者用焦虑自评量表(SAS)和抑郁自评量表(SDS)检测,无精神症状者23例为一组;有精神症状者102例,随机分成3组,各组治疗前后分别用SAS和SDS检测;对照组予香砂养胃丸,8丸,每天3次,吗叮啉1片,三餐前口服,观察组在对照组的基础上分别加服黛力新1片,每天1次,或氟西汀20mg,每天1次;疗程均为6周,比较治疗前后消化道症状和精神症状的变化。结果观察组治疗前后消化道症状和精神症状明显缓解(P<0.01),对照组无精神症状组,治疗前后消化道症状明显缓解(P<0.01),对照组有精神症状组,治疗前后消化道症状和精神症状无明显缓解(P<0.05),各组均无明显副作用。结论联合黛力新或氟西汀治疗FD疗效满意,安全性好,黛力新比氟西汀起效更快、更经济;对无精神症状的FD无需合用抗抑郁、焦虑药物。
Objective To evaluate the efficacy of combined treatment with or with fluoxetine in the treatment of functional dyspepsia (FD). Methods A total of 125 patients with FD were tested by SAS and SDS, 23 with no psychotic symptoms and 102 with psychotic symptoms were randomly divided into 3 groups, each group Before and after treatment with SAS and SDS test; control group to Xiangshayangwei pills, 8 pills, 3 times a day, Morindromycin 1 tablets, three meals before oral administration group were added on the basis of the control group Deanxit 1 tablet, once daily or fluoxetine 20mg once daily. The course of treatment was 6 weeks. The changes of gastrointestinal symptoms and mental symptoms before and after treatment were compared. Results Before and after treatment, the symptoms of gastrointestinal tract and mental symptoms in the observation group were relieved (P <0.01), while those in the control group without psychotic symptoms were relieved before and after treatment (P <0.01). In the control group, there were psychotic symptoms, digestive tract before and after treatment Symptoms and mental symptoms were not significantly relieved (P <0.05), no significant side effects in all groups. Conclusions The combination of dextromethorphan or fluoxetine in the treatment of FD is effective and safe. Dextromethorphan is faster and more economical than fluoxetine, and there is no need for antidepressant and anxiety drugs for FD without psychotic symptoms.