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Pai R K,Jayachandran P,Koong A C,et al.BRAF-mutated,microsatellite-stable adenocarcinoma of the proximal colon:anaggressive adenocarcinoma with poor survival,mucinous differ-entiation,and adverse morphologic features.Am J Surg Pathol,2012,36(5):744-52.BRAF V600E突变、CpG岛甲基化表型(CIMP)的存在以及微卫星不稳定(MSI)之间的关系经常使得结直肠癌BRAF突变状态和其生存率的分析变得混乱。作者对一组
Pai RK, Jayachandran P, Koong AC, et al. BRF F-mutated, microsatellite-stable adenocarcinoma of the proximal colon: an aggressive human colicoma with poor survival, mucinous differ- entiation, and adverse morphologic features. Am J Surg Pathol, 2012, 5): 744-52.BRAF V600E mutation, presence of CpG island methylation phenotype (CIMP), and microsatellite instability (MSI) often make the analysis of BRAF mutation status and its survival rate of colorectal cancer variable To be confused. Author of a group