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前期研究把家族性鼻咽癌(NPC)候选易感位点定位在长度约14.21cM的4p15.1～q12区域上,但由于微卫星标记D4S2996和D4S428没有提供足够信息,这个区域的远端边界没有得到最大程度的确定.在两个主要的NPC家系中采用一组微卫星标记和单核苷酸多态性标记进行单体型分析,将NPC易感区域的远端边界确定于D4S1577和D4S3347之间,并将该区域缩小到长度为8.29cM的4p11～p14区域.
Previous studies identified susceptibility loci for familial NPC candidates on the 4p15.1 ~ q12 region of about 14.21 cM in length, but since the microsatellite markers D4S2996 and D4S428 did not provide sufficient information, the remote border of this region Was not determined to the greatest extent.Using a panel of microsatellite markers and single nucleotide polymorphism markers for haplotyping in the two major NPC families, the distal boundary of the susceptible region of NPC was identified at D4S1577 and D4S3347 And narrowed the region to the 4p11-p14 region of 8.29 cM in length.