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抑癌基因的失活或癌基因的激活与肿瘤的发生、发展关系密切。抑癌基因的点突变、重组、缺失或甲基化所致的功能失活与多种人类恶性肿瘤的发生及发展有关。抑癌基因编码的蛋白质具有多种功能。在肿瘤的发生过程中，抑癌基因的失活比原癌基因的激活起着更关键的作用。
Tumor suppressor gene inactivation or oncogene activation and tumor occurrence and development are closely related. Point mutations in tumor suppressor genes, recombination, deletion or methylation-induced loss of function and a variety of human malignancies and development. The protein encoded by tumor suppressor gene has many functions. In tumorigenesis, inactivation of tumor suppressor genes plays a more critical role than oncogene activation.