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1 引 言 我国每年大量出口乌鸡白凤丸等传统中药,但许多国家和地区对药中汞的含量仍有严格的要求(不得超过 0.5μg/g),而目前国内外无统一可依据的测定中成药中汞含量方法.因此急须建立统一有效的规范方法.目前,国内外测定汞的方法有许多种,在诸多方法中,以冷蒸气原子吸收分光光谱法(CVAAS)最为理想,该法灵敏度高,检测限低.但影响该法的因素较多,因此选择最佳实验条件就成了CVAAS法成败的关键,本文详细研究优化了CVAAS法测定中成药中汞含量各种最佳实验条件,并建立了CVAAS法测定中成药中汞含量的方法,实测某厂 3批乌鸡白凤丸,所得汞含量在 0.5～0.65μg/g之间.2 实验与方法2.1 仪器与试剂 S-H-22型原子吸收分光光度仪(Themo Jarrell Ash Corporation,美国产品),汞空心阴极灯(北京电子动力公司电子仪器厂产品);ILAVATA冷蒸气发生装置(Themo Jarrell Corporation,美国产品);50 mL消解器(聚四氟乙烯);高纯氩气(99.999％);去离子水(自制);其它均为 AR纯化学试剂,市售药品.2.2 实验条件的选择
1 Introduction China exports a large number of traditional Chinese medicines such as Wuji Baifeng Wan every year. However, many countries and regions still have strict requirements on the mercury content (no more than 0.5 μg / g). However, at present, Therefore, there is an urgent need to establish a unified and effective standardization method.At present, there are many methods for the determination of mercury in the world, and in many methods the most ideal method is the cold vapor atomic absorption spectrometry (CVAAS), the sensitivity High, low detection limit.But there are many factors affecting the method, so the choice of the best experimental conditions has become the key to the success or failure of the CVAAS method.In this paper, the best CVAAS method for the determination of mercury in the Chinese medicine the best experimental conditions, And established a method for the determination of mercury in Chinese traditional medicine by the CVAAS method. Three batches of Wujibaifeng pill in a factory were measured, and the mercury content was between 0.5 and 0.65 μg / g.2 Experiments and Methods 2.1 Instruments and reagents SH-22 type atom Absorption spectrophotometer (Themo Jarrell Ash Corporation, U.S.A.), mercury hollow cathode lamp (manufactured by Beijing Electronics Engine Co.); ILAVATA cold vapor generator (Themo Jarrell Corporation, U.S.A.); 50 mL digestion device (polytetrafluoroethylene); high purity argon (99.999%); deionized water (homemade); the other are AR pure chemical reagents, commercially available drugs.2.2 experimental conditions of choice