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Xp11易位癌包括Xp11易位性肾细胞癌(RCC)、Xp11易位性血管周上皮样细胞肿瘤(PEComa)以及色素性Xp11易位肾癌。在Xp11易位癌中,TFE3与一些不同基因伴侣的融合,从而激活TFE3致癌基因;然而不同的融合变异体对Xp11易位癌的临床病理特点影响尚不清楚。本文使用定制的细菌人工染色体探针来建立TFE3融
Xp11 translocations include Xp11 translocation renal cell carcinoma (RCC), Xp11 translocation perivascular epithelial cell tumor (PEComa) and pigmentary Xp11 translocation renal carcinoma. In Xp11 translocations, TFE3 is fused with several different genetic partners to activate the TFE3 oncogene; however, the effect of different fusion variants on the clinicopathological features of Xp11 translocations is unclear. This article uses a custom bacterial artificial chromosome probe to establish TFE3 fusion