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目的研究结肠直肠癌基质金属蛋白酶7(MMP-7)和血管内皮生长因子A(VEGF-A)的表达对结肠直肠癌侵袭和转移的影响。方法采用免疫组织化学法检测86例大肠癌组织和10例正常组织中MMP-7和VEGF-A的表达情况。结果在86例结肠直肠癌组织中MMP-7的阳性表达率为65.1%,VEGF-A为50%,与对照组比较有非常显著性差异(P<0.01)。VEGF-A和MMP-7的表达与结肠直肠癌淋巴结转移、分化程度、Ducks分期相关(P<0.05),与性别无关(P>0.05)。VEGF-A的表达与MMP-7的表达呈正相关(P<0.01)。结论大肠癌中MMP-7、VEGF-A的表达与肿瘤侵袭转移密切相关,可作为判断大肠癌恶性程度、转移及预后的重要参考指标。
Objective To investigate the effect of matrix metalloproteinase 7 (MMP-7) and vascular endothelial growth factor A (VEGF-A) on the invasion and metastasis of colorectal cancer. Methods The expression of MMP-7 and VEGF-A in 86 colorectal cancer tissues and 10 normal tissues was detected by immunohistochemistry. Results The positive expression rate of MMP-7 in 65 colorectal cancer tissues was 65.1% and VEGF-A was 50%, which was significantly different from the control group (P <0.01). The expression of VEGF-A and MMP-7 was correlated with lymph node metastasis, differentiation degree and Ducks stage (P <0.05) in colorectal cancer, but not with sex (P> 0.05). The expression of VEGF-A was positively correlated with the expression of MMP-7 (P <0.01). Conclusion The expression of MMP-7 and VEGF-A in colorectal carcinoma is closely related to tumor invasion and metastasis, which can be used as an important reference index to determine the malignant degree, metastasis and prognosis of colorectal cancer.