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目的:探讨大剂量青霉素类、链霉素、头孢菌素类治疗感染性心内膜炎的临床效果。方法:选取我院2007-2011年收治的76例感染性心内膜炎患者,其中,男性40例,年龄在18-54岁之间,女性36例,年龄在21-61岁之间,所有患者均经临床诊断为感染性心内膜炎。将76例患者随机分为两组,观察组39例,对照组37例,观察组患者采用大剂量的青霉素类、链霉素、头孢菌素类进行治疗,对照组患者采用常规剂量的青霉素类、链霉素、头孢菌素类进行治疗,对两组患者的治疗过程进行跟踪观察,并记录所得数据。结果:经过一系列的治疗,两组患者的病情均有一定程度的改善。观察组39例患者中,显效22例,有效14例,无效3例,有效率为92.3%;对照组37例患者中,显效16例,有效13例,无效8例,有效率为78.4%。观察组患者的治疗效果显著优于对照组,对患者病情的改善帮助较大。结论:临床在治疗感染性心内膜炎疾病的过程中,采用大剂量的青霉素类、链霉素、头孢菌素类,治疗效果较为显著,对患者的帮助较大,值得在临床上推广应用。
Objective: To investigate the clinical effect of high dose penicillins, streptomycin and cephalosporins in the treatment of infective endocarditis. Methods: A total of 76 patients with infective endocarditis admitted in our hospital from 2007 to 2011 were enrolled. Among them, 40 were males, aged 18-54 and 36 females, aged 21-61 years Patients were clinically diagnosed as infective endocarditis. 76 patients were randomly divided into two groups, the observation group 39 cases, the control group 37 cases, the observation group patients with high doses of penicillins, streptomycin, cephalosporins for treatment, the control group patients with conventional doses of penicillins , Streptomycin, cephalosporins for treatment, follow-up observation of the treatment of two groups of patients, and record the data obtained. Results: After a series of treatment, the two groups of patients have a certain degree of improvement in the condition. Among the 39 patients in the observation group, 22 were markedly effective, 14 were effective, 3 were ineffective, and the effective rate was 92.3%. Of the 37 patients in the observation group, 16 were markedly effective, 13 were effective, 8 were ineffective, and the effective rate was 78.4%. The observation group patients treatment effect was significantly better than the control group, to improve the condition of the patient to help larger. Conclusion: The clinical treatment of infective endocarditis in the process, the use of high doses of penicillins, streptomycin, cephalosporins, the treatment effect is more significant, greater help to patients, it is worth in the clinical application .