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目的:总结国内外关于微小RNADNA甲基化在肿瘤发生发展过程的作用及其进行靶向调控的研究现状。方法:应用Medline及CNKI期刊全文数据库检索系统,以“肿瘤、微小RNA、DNA甲基化”为关键词,检索1993-01-2010-01的相关文献,共检索到英文文献62篇和中文文献2篇。纳入标准:1)微小RNA的起源和特点;2)微小RNA与DNA甲基化的关系;3)微小RNADNA甲基化与肿瘤发生发展的关系;4)微小RNADNA甲基化与肿瘤预后的关系。根据纳入标准符合分析文献23篇。结果:DNA甲基化可能是一种导致miRNA在肿瘤中表达沉默并影响其靶基因的表达和功能,进而影响肿瘤生物学行为的重要方式。结论:微小RNADNA甲基化是肿瘤发生发展的重要机制之一,为肿瘤的诊断及治疗提供了新的方法。
OBJECTIVE: To summarize the current status of the research on the role of microRNA RNA methylation in tumorigenesis and development as well as its targeted regulation. Methods: Using the Medline and CNKI journal full-text database retrieval system, we searched the related literature of 1993-01-2010-01 with the keywords of “tumor, microRNA and DNA methylation”, and retrieved 62 articles in English and Chinese literature 2. Inclusion criteria: 1) the origin and characteristics of microRNAs; 2) the relationship between microRNAs and DNA methylation; 3) the relationship between microRNAs DNA methylation and tumorigenesis; 4) the relationship between microRNAs DNA methylation and tumor prognosis . Accordance with the inclusion criteria in line with the analysis of 23 articles. Results: DNA methylation may be an important way to cause the expression of miRNA in the tumor and affect the expression and function of its target gene, thereby affecting the biological behavior of the tumor. Conclusion: MicrRNA DNA methylation is one of the important mechanisms of tumorigenesis, which provides a new method for the diagnosis and treatment of tumors.