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目的 对四川省首起可疑传染性非典型肺炎 (SARS)的家庭暴发病例进行流行病学调查 ,病原学、血清学检测 ,明确诊断。方法 对发生于 2 0 0 3年 2月 12日的首起家庭暴发病例进行流行病学调查 ,病原学和血清学检测。结果 该起暴发发生于四川省广元市某厂 ,1家 3口皆发病 ,有密切接触史 ,符合传染性非典型肺炎的临床诊断标准。患者鼻和咽拭子 ,上呼吸道分泌物标本 ,均未分离到流感病毒 ,禽流感病毒和肺炎衣原体。患者A恢复期血冠状病毒IgM和IgG抗体阳性 ,患者B恢复期血冠状病毒IgG抗体阳性 ,患者C急性期血冠状病毒和肺炎衣原体IgM抗体阳性。 结论 该起暴发的流行病学、临床特征、血清学等均符合传染性非典型肺炎的诊断。为四川省首起传染性非典型肺炎疫情
Objective To carry out epidemiological investigation, etiological and serological tests on cases of domestic outbreak of the first suspected SARS in Sichuan Province and confirm the diagnosis. Methods Epidemiological, etiological and serological tests were performed on the first cases of domestic outbreaks that occurred on February 12, 2003. The outbreak occurred in Guangyuan City, Sichuan Province, a factory, a 3 were all incidence, have close contact with history, in line with the clinical diagnosis of SARS diagnostic criteria. Patients with nasal and throat swabs, upper respiratory secretions specimens, did not isolate the influenza virus, bird flu virus and Chlamydia pneumoniae. Patients with convalescent blood coronavirus IgM and IgG antibody positive, patients with convalescent blood coronavirus IgG antibody positive, C patients with acute coronavirus and Chlamydia pneumoniae IgM antibody positive. Conclusions The epidemiology, clinical characteristics, serology, etc. of the outbreak are in line with the diagnosis of SARS. It is the first outbreak of SARS in Sichuan Province