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研究了关附己素（１０ｍｇ·ｋｇ~（－１），ｉＶ）和普罗帕酮（４ｍ９·ｋｇ~（－１），ｉＶ）对麻醉大鼠血流动力学的影响。结果表明，关附己素与普罗帕酮均可显著延长大鼠心电图Ｐ－Ｐ间期、Ｐ－Ｒ间期、ＱＲＳ波群以及Ｑ－Ｔ间期。而前者的作用时间更为持久。本品可显著抑制ＨＲ、±（ｄｐ／ｄｔ）ｍａｘ和（ｄｐ／ｄｔ）·ｐ－１ｍａ＝ｘ，但不影响ＬＶＳＰ、ＬＶＥＤＰ。关附己素对ＳＡＰ无影响，但对ＭＡＰ和ＤＡＰ有明显的一过性降低作用。而普罗帕酮除对ＬＶＥＤＰ无影响外，对上述所有参数均有显著抑制作用。上述结果提示，关附己素可抑制心内冲动传导，对心率抑制较强，且延长心舒张期，而对动脉血压影响较小。
The effects of metoprolol (10 mg · kg -1, iV) and propafenone (4m9 · kg -1, iV) on hemodynamics in anesthetized rats were studied. The results showed that both Guanhexin and Propafenone could significantly prolong the electrocardiogram P-P interval, P-R interval, QRS wave group and Q-T interval. The role of the former more lasting time. This product can significantly inhibit the HR, ± (dp / dt) max and (dp / dt) · p-1ma = x, but does not affect LVSP, LVEDP. Metapretin did not affect SAP, but had a marked and transient reduction of MAP and DAP. Propafenone had no significant effect on all the above parameters except LVEDP. The above results suggest that Guanhexintin can inhibit intracardiac impulse conduction, inhibition of heart rate stronger and prolongation of cardiac diastolic period, while less impact on arterial blood pressure.