晚期头颈癌治疗是一困难的问题,其治疗主要依据肿瘤的原发部位、扩展范围、颈淋巴结和病人的身体及精神的情况而定。多年来,联合或单独采用手术和放射进行治疗,但用以治疗大的、伴有或不伴有晚期淋巴结转移的肿瘤,其复发及远处转移的发生率高;这就提示了对晚期头颈癌的治疗还应应用如化疗之类的全身疗法。为评价顺氯胺铂和博莱霉素治疗晚期头颈癌的效用,作者于1976～1979年选择的71例已经临床及放射学检查确定不能切除的原发或颈部转移但尚无远处转移的鳞状细胞癌患者71例,分成三组进行观察研究。第一组24人,行诱导化疗、手术及术后放疗;第二组23人,化疗后放疗;第三组24人,单用化疗,后将其作为对照组与前二组进行比较分析。化疗方法是在第1、22天每人给 The treatment of advanced head and neck cancer is a difficult problem, and its treatment is mainly based on the primary site of the tumor, the expanded range, the cervical lymph nodes, and the patient’s physical and mental conditions. For many years, surgery and radiation have been used in conjunction or alone to treat large tumors with or without advanced lymph node metastases. The incidence of recurrence and distant metastases is high; this suggests a late head and neck The treatment of cancer should also apply systemic therapies such as chemotherapy. To evaluate the efficacy of cisplatin and bleomycin in the treatment of advanced head and neck cancers, the authors selected 71 patients from 1976 to 1979 who had clinical and radiological examination to determine the primary or cervical metastases that could not be removed but had no distant metastases. Seventy-one patients with squamous cell carcinoma were divided into three groups for observational studies. The first group of 24 patients received induction chemotherapy, surgery, and postoperative radiotherapy; 23 patients in the second group received radiotherapy after chemotherapy; 24 patients in the third group received chemotherapy alone, and were compared and analyzed as the control group and the first two groups. Chemotherapy was given on each of the 1st and 22nd days.